Unorthodox cascade reaction of arynes and N -nitrosamides leading to indazole scaffolds.
Popuri SureshbabuVinod BhajammanavarVenkata Surya Kumar ChoutipalliVenkatesan SubramanianMahiuddin BaidyaPublished in: Chemical communications (Cambridge, England) (2022)
An unusual cascade annulation of arynes with N -alkyl- N -nitrosamides is developed by leveraging aryne σ-insertion and C(sp 3 )-H bond functionalization strategies under transition-metal-free conditions at ambient temperature, offering functionalized indazoles in high yields and regioselectivity. The protocol is scalable and exhibits a broad substrate scope. The reaction mechanism is also studied with DFT calculations.
Keyphrases
- density functional theory
- air pollution
- randomized controlled trial
- electron transfer
- particulate matter
- molecular dynamics
- molecular dynamics simulations
- ionic liquid
- molecular docking
- quantum dots
- tissue engineering
- molecularly imprinted
- high resolution
- mass spectrometry
- structural basis
- tandem mass spectrometry