In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.

Thomas A LegøyLuiza M GhilaHeidrun VetheShadab AbadpourAndreas F MathisenJoao A PauloHanne ScholzHelge RaederSimona Chera

Published in: Acta physiologica (Oxford, England) (2020)

Hyperglycaemia exposure induced distinct, period-dependent, negative effects on xenotransplanted human pancreatic progenitor, affecting their energy homeostasis, cell fate acquisition and survival.

Keyphrases

cell fate
endothelial cells
oxidative stress
diabetic rats
induced pluripotent stem cells
high glucose
pluripotent stem cells
dna damage
ischemia reperfusion injury
drug induced
stress induced