The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation.
Johanna K FreundtGerrit FrommeyerFabian WötzelAndreas HugeAndreas HoffmeierSven MartensLars EckardtPhilipp Sebastian LangePublished in: BioMed research international (2018)
ATF4 is expressed in human atrial cardiomyocytes and is induced in response to different types of cell stress. High rate electrical field stimulation seems to result in ATF4 induction, and forced expression of ATF4 reduces cardiomyocyte viability.
Keyphrases
- transcription factor
- high glucose
- atrial fibrillation
- endoplasmic reticulum stress
- endothelial cells
- poor prognosis
- single cell
- cell therapy
- genome wide identification
- left atrial
- dna binding
- catheter ablation
- genome wide
- long non coding rna
- gene expression
- stem cells
- dna methylation
- coronary artery disease
- oral anticoagulants
- direct oral anticoagulants
- mesenchymal stem cells
- bone marrow