hEPCR.hTBM.hCD47.hHO-1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
Arielle CimenoKasinath KuraviLori SorrellsAmy DandroSelin SendilLars BurdorfDawn M ParsellWill EyestoneCarol PhelpsDavid AyaresAgnes M AzimzadehRichard N PiersonRolf N BarthJohn C LaMattinaPublished in: Xenotransplantation (2022)
The combination of the hEPCR.hTBM.hCD47.hHO-1 cassette along with donor pig DDAVP and clodronate liposome pretreatment was associated with prolonged function of xenoperfused livers, reduced coagulation pathway perturbations, and decreased TXB2 elaboration, and reflects significant progress to modulate liver xenograft injury in a pig to human model.