Spatial Mapping of Hematopoietic Clones in Human Bone Marrow.
Andrew L YoungHannah C DavisMaggie J CoxTyler M ParsonsSamantha C BurkartDiane E BenderLulu SunStephen T OhGrant A ChallenPublished in: Blood cancer discovery (2024)
CH occurs commonly in humans and can predispose to hematologic malignancy. Although well characterized in blood, it is poorly understood how clones are spatially distributed in the bone marrow. To answer this, we developed methods for spatially aware somatic mutation profiling to describe clonal heterogeneity in human bone marrow. See related commentary by Austin and Aifantis, p. 139.