Neoadjuvant therapy alters the collagen architecture of pancreatic cancer tissue via Ephrin-A5.

Kosei NakajimaYoshinori InoChie NaitoSatoshi NaraMari ShimasakiUtako IshimotoToshimitsu IwasakiNoriteru DoiMinoru EsakiYoji KishiKazuaki ShimadaNobuyoshi Hiraoka

Published in: British journal of cancer (2021)

These results suggest that effective NAT changes the extracellular matrix with collagen profiles through CAFs and their Ephrin-A5 expression.

Keyphrases

extracellular matrix
poor prognosis
rectal cancer
wound healing
tissue engineering
locally advanced
binding protein
mesenchymal stem cells
replacement therapy