Pramipexole Augmentation for Treatment-Resistant Unipolar and Bipolar Depression in the Real World: A Systematic Review and Meta-Analysis.

Antonio Tundo Sophia Betro'Rocco de FilippisFulvia MarchettiDaniele NaccaRoberta NecciMarica Iommi

Published in: Life (Basel, Switzerland) (2023)

The findings of this systematic review, needing further confirmation, show that off-label use of pramipexole as augmentation of antidepressant treatment could be a useful and safe strategy for unipolar and bipolar treatment-resistant depression.

Keyphrases

systematic review
bipolar disorder
depressive symptoms
major depressive disorder
sleep quality
meta analyses
soft tissue
randomized controlled trial
combination therapy
replacement therapy