Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives.

Martin E HaleJames E WildTadaaki YamadaTakaaki YokotaJan TackViola AndresenAsbjørn Mohr Drewes

Published in: Therapeutic advances in gastroenterology (2021)

This integrated analysis further supports the efficacy and tolerability of naldemedine in the treatment of OIC and demonstrates a consistent effect in both PLR and non-PLR subgroups.[ClinicalTrials.gov identifier: NCT01965158 and NCT01993940].

Keyphrases

chronic pain
pain management
randomized controlled trial
spinal cord injury
squamous cell carcinoma
open label
diabetic rats
double blind
study protocol
data analysis