Intratunical injection of rat-derived bone marrow mesenchymal stem cells prevents fibrosis and is associated with increased Smad7 expression in a rat model of Peyronie's disease.

Wenting WangWeifang DingXuebao ZhangShuang WuTianxi YuXin CuiYaqi XieDiandong YangChun-Hua Lin

Published in: Stem cell research & therapy (2022)

The antifibrotic effects of BMSCs treatment in the active phase of the PD rat model were better than those in the chronic phase. A possible mechanism of BMSCs treatment was related to increased Smad7 expression, suggesting a possible effective and safe procedure for the treatment of PD.

Keyphrases

poor prognosis
epithelial mesenchymal transition
oxidative stress
transforming growth factor
combination therapy
signaling pathway
drug induced
smoking cessation