Functions of lncRNA DUXAP8 in non-small cell lung cancer.
Cui WuWu SongZhongnan WangBingmei WangPublished in: Molecular biology reports (2022)
Non-small cell lung cancer (NSCLC) poses a serious threat to public health due to its significant morbidity and mortality rates. The processes of NSCLC formation and development are quite complex and involve numerous regulatory biomolecules. Long non-coding RNAs (lncRNAs) have attracted attention since they have been found to play critical roles in the tumorigenesis of various human malignancies. Recently, double homeobox A pseudogene 8 (DUXAP8) was identified as an oncogenic lncRNA that is overexpressed in different tumor types. In NSCLC, high expression of DUXAP8 is associated with poor prognosis in patients. The regulatory mechanism underlying the oncogenic effects of DUXAP8 can be divided into transcriptional level and post-transcriptional level. DUXAP8 promotes proliferation, epithelial-mesenchymal transition, and aerobic glycolysis in NSCLC cells. Moreover, DUXAP8 shows potential for the diagnosis and treatment of NSCLC. Herein, we review the molecular mechanisms underlying the DUXAP8-mediated phenotypes of NSCLC as well as its potential clinical applications.
Keyphrases
- poor prognosis
- long non coding rna
- small cell lung cancer
- advanced non small cell lung cancer
- transcription factor
- public health
- epithelial mesenchymal transition
- brain metastases
- signaling pathway
- endothelial cells
- induced apoptosis
- newly diagnosed
- prognostic factors
- end stage renal disease
- risk assessment
- working memory
- patient reported outcomes
- long noncoding rna
- binding protein
- pi k akt
- network analysis
- patient reported
- human health