How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis.
Nicholas G CunniffeSimon J GunterMichael BrownSarah W BurgeClare CoyleAnthony De SoyzaTom DymondHanif EsmailDarrel P FrancisJacqui GallowayJames B GallowayEffrossyni Gkrania-KlotsasJane GreenawayGeorge KatritsisPrapa KanagaratnamMartin D KnolleKelly LeonardZoe C McIntyreBen PrudonTommy RamplingMichelle S TolemanBen WarneMark YatesNicholas J MathesonLi SuSofia VillarGrant D StewartMark ToshnerPublished in: BMJ open (2020)
Feasible recruitment rates, study design and proliferation of trials can limit the number, and size, that will successfully complete recruitment. We consider that fewer, more appropriately designed trials, prioritising cooperation between centres would maximise productivity in a further wave.