Parent-Mediated Interventions for Infants under 24 Months at Risk for Autism Spectrum Disorder: A Systematic Review of Randomized Controlled Trials.
Mei Lin LawJatinder SinghMathilde MastroianniParamala J SantoshPublished in: Journal of autism and developmental disorders (2021)
Prodromal symptoms of Autism Spectrum Disorder (ASD) have been detected within the first year of life. This review evaluated evidence from randomized controlled trials (RCTs) of parent-mediated interventions for infants under 24 months who are at risk for ASD. Electronic databases, including grey literature, were searched up till November 2019. Seven RCTs were identified. There was substantial heterogeneity in recruitment, outcome measures and effect size calculations. Interventions did not reduce the risk of later ASD diagnosis and post-intervention effects on infant outcomes were inconsistent, with five studies reporting significant improvements across both treatment and control groups. Moderate level of evidence of intervention effects on parental interaction skills and the small number of RCTs, and significant limitations restrict generalizability across studies.
Keyphrases
- autism spectrum disorder
- randomized controlled trial
- intellectual disability
- attention deficit hyperactivity disorder
- physical activity
- systematic review
- case control
- single cell
- clinical trial
- density functional theory
- emergency department
- molecular dynamics simulations
- parkinson disease
- high intensity
- white matter
- multiple sclerosis
- medical students
- skeletal muscle
- depressive symptoms
- insulin resistance