Tumor-Infiltrating Lymphocytes Refine Outcomes in Triple-Negative Breast Cancer Treated with Anthracycline-Free Neoadjuvant Chemotherapy.

Miguel Martin Rachel Yoder Roberto Salgado Maria Del Monte-Millán Enrique L Álvarez Isabel Echavarría Joshua M Staley Anne P O'Dea Lauren E Nye Shane R Stecklein Coralia Bueno Yolanda Jerez María Cebollero Oscar Bueno José Angel García-Saenz Fernando Moreno Antón Uriel Bohn Henry L Gómez Tatiana Massarrah Qamar J Khan Andrew K Godwin Miguel Martín Priyanka Sharma

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

sTILs density was an independent predictor of OS beyond clinicopathologic features and pathologic response in patients with TNBC treated with anthracycline-free CbD chemotherapy. Notably, sTILs density stratified outcomes beyond tumor-node-metastasis (TNM) stage and pathologic response. These findings highlight the role of sTILs in patient selection and stratification for neo/adjuvant escalation and de-escalation strategies.

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