Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice.

Sarah RaevensAnja GeertsAnnelies ParidaensSander LefereXavier VerhelstAnne HoorensJo Van DorpeTania MaesKen R BrackeChristophe CasteleynBart JonckxThomas HorvatitsValentin FuhrmannHans Van VlierbergheChristophe Van SteenkisteLindsey DevisscherIsabelle Colle

Published in: Hepatology (Baltimore, Md.) (2018)

CBDL in mice induces HPS, which is mediated by PlGF production; αPlGF treatment improves experimental HPS by counteracting pulmonary angiogenesis and might be an attractive therapeutic strategy for human HPS. (Hepatology 2017).

Keyphrases

growth factor
endothelial cells
pulmonary hypertension
high fat diet induced
vascular endothelial growth factor
wound healing
case report
induced pluripotent stem cells
wild type
adipose tissue
pluripotent stem cells
smoking cessation