AZGP1 Up-Regulation is a Potential Target for Andrographolide Reversing Radioresistance of Colorectal Cancer.
Ye-Ying FangJin-Mei HuangJia-Ying WenJian-Di LiJin-Hai ShenDa-Tong ZengYan-Fang PanHe-Qing HuangZhi-Guang HuangLi-Min LiuGang ChenPublished in: Pharmacogenomics and personalized medicine (2022)
AZGP1 is recognized as a crucial factor for both CRC initiation and radioresistance. Andrographolide may affect the radioresistance of CRC via the targeting of AZGP1. Thus, the combination of andrographolide and AZGP1 intervention might be a promising strategy for improving the treatment benefit of CRC radiotherapy.