Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression.

Jessica L FaragherJennifer L AugerVictoria OsinskiLee A MeierBrianna J EngelsonMaria M FirulyovaMayra I Gonzalez-TorresFrank BrombacherKonstantin ZaitsevAubyn Marath Bryce A Binstadt

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

TNF and IL-6 are the main cytokines driving valvular carditis in K/B.g7 mice. The interaction of TNF with TNFR1 specifically on endothelial cells promotes cardiovascular pathology in the setting of systemic autoimmune/rheumatic disease, suggesting that therapeutic targeting of the TNF:TNFR1 interaction could be beneficial in this clinical context.

Keyphrases

endothelial cells
rheumatoid arthritis
atrial fibrillation
multiple sclerosis
poor prognosis
high glucose
aortic valve
drug induced
type diabetes
oral anticoagulants
vascular endothelial growth factor
cancer therapy
metabolic syndrome
high fat diet induced
insulin resistance
drug delivery