Escalation of alcohol intake is associated with regionally decreased insular cortex activity but not associated with changes in taste quality.
A MukherjeeM S PaladinoS L McSainE A Gilles-ThomasD D LichteR D CamadineS WillockK V SontateS C HoneycuttGregory C LoneyPublished in: Alcoholism, clinical and experimental research (2023)
Our results demonstrate that neural activity within the IC adapts following repeated presentations of EtOH in a manner that correlates with reduced sensitivity to the aversive hedonic properties of EtOH. These data further establish that alterations in IC activity may be driving exposure-induced escalations in EtOH intake.