Down-regulated miR-146a expression with increased neutrophil extracellular traps and apoptosis formation in autoimmune-mediated diffuse alveolar hemorrhage.

Yu-Tung HsiehYu-Chi ChouPin-Yu KuoHung-Wen TsaiYi-Ting YenAi-Li ShiauChrong-Reen Wang

Published in: Journal of biomedical science (2022)

Our results demonstrate firstly down-regulated pulmonary miR-146a levels with increased TRAF6 and IL-8 expression and NETs and apoptosis formation in autoimmune-mediated DAH, and implicate a therapeutic potential of intra-pulmonary miR-146a delivery.

Keyphrases

long non coding rna
poor prognosis
cell proliferation
long noncoding rna
oxidative stress
pulmonary hypertension
endoplasmic reticulum stress
cell cycle arrest
multiple sclerosis
cell death
transcription factor