TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis.
Maura RossettiRoberto SpreaficoAlessandro ConsolaroJing Yao LeongCamillus ChuaMargherita MassaSuzan SaidinSilvia Magni-ManzoniThaschawee ArkachaisriCarol A WallaceMarco GattornoAlberto MartiniDaniel J LovellSalvatore AlbaniPublished in: Annals of the rheumatic diseases (2016)
Using an innovative antigen-agnostic approach, we uncovered a population of bona fide synovial Treg cells readily accessible from the blood and selectively expanding during active disease, paving the way to non-invasive diagnostics and better understanding of the pathogenesis of autoimmunity.
Keyphrases
- single cell
- induced apoptosis
- endothelial cells
- oxidative stress
- cell cycle arrest
- rheumatoid arthritis
- cell therapy
- regulatory t cells
- genome wide
- induced pluripotent stem cells
- pluripotent stem cells
- gram negative
- klebsiella pneumoniae
- gene expression
- bone marrow
- mesenchymal stem cells
- dna methylation
- celiac disease