Longitudinal cognitive performance of Alzheimer's disease neuropathological subtypes.
Madeline UretskyLaura E GibbonsShubhabrata MukherjeeEmily H TrittschuhDavid W FardoPatricia A BoyleC Dirk KeeneAndrew J SaykinPaul K CraneJulie A SchneiderJesse B MezPublished in: Alzheimer's & dementia (New York, N. Y.) (2021)
The relative frequencies of AD neuropathological subtypes in an epidemiological sample were consistent with a previous report in a convenience sample. People with HpSpAD decline rapidly, but may not have a memory-sparing clinical syndrome. Cohort-specific differences in regional tau burden and comorbid neuropathology may explain the lack of clinicopathological correlation.