Ricolinostat promotes the generation of megakaryocyte progenitors from human hematopoietic stem and progenitor cells.
Jianan JiangJinhua QinJisheng LiXiaosong LinBowen ZhangZeng FanLijuan HeQuan ZengWen YueMin ZhengXuetao PeiYanhua LiPublished in: Stem cell research & therapy (2022)
The addition of Ricolinostat to the culture medium promoted MkP differentiation from HSPCs and enhanced the proliferation of MkPs mainly by suppressing the IL-8/CXCR2 pathway. Our results can help the development of manufacturing protocols for the efficient generation of MKs and platelets from stem cells in vitro.