Cardamom Extract Alleviates the Oxidative Stress, Inflammation and Apoptosis Induced during Acetaminophen-Induced Hepatic Toxicity via Modulating Nrf2/HO-1/NQO-1 Pathway.
Essraa A R AlkhalifahAmjad A AlobaidMarwah A AlmajedManar K AlomairLama S AlabduladheemSarah F Al-SubaieAbdullah AkbarMahesh V AttimaradNancy S YounisMaged E MohamedPublished in: Current issues in molecular biology (2022)
CARD extract mitigated the hepatic toxicity induced by APAP. The underlying mechanism of action of such hepato-protective action may be through upregulation of the Nrf2/HO-1/NQO-1 pathway with subsequent alleviation of the oxidative stress, inflammation and apoptosis induced by APAP. Many of the compounds identified in the CARD extract could be attributed to this pharmacological action of the extract.