Common Trajectories of Highly Effective CD19-Specific CAR T Cells Identified by Endogenous T-cell Receptor Lineages.
Taylor L WilsonHyunjin KimChing-Heng ChouDeanna M LangfittRobert C MettelmanAnastasia A MinervinaEmma Kaitlynn AllenJean-Yves MetaisMikhail V PogorelyyJanice M RiberdyMireya Paulina VelasquezPratibha KottapalliSanchit TrivediScott R OlsenTimothy D LockeyCatherine WillisMichael M MeagherBrandon M TriplettAimee C TalleurStephen GottschalkJeremy Chase CrawfordPaul Glyndwr ThomasPublished in: Cancer discovery (2022)
Utilizing clonal trajectories to define transcriptional potential, we find a unique signature of CAR T-cell effector precursors present in preinfusion cell products. Functional assessment of cells with this signature indicated early effector potential and resistance to exhaustion, consistent with postinfusion cellular patterns observed in patients. This article is highlighted in the In This Issue feature, p. 2007.
Keyphrases
- induced apoptosis
- end stage renal disease
- cell cycle arrest
- single cell
- depressive symptoms
- chronic kidney disease
- cell therapy
- ejection fraction
- regulatory t cells
- dendritic cells
- machine learning
- gene expression
- transcription factor
- peritoneal dialysis
- type iii
- cell death
- cell proliferation
- signaling pathway
- patient reported outcomes
- human health
- climate change
- heat shock