Unraveling the Connection: Extracellular Vesicles and Non-Small Cell Lung Cancer.
Jiankang WuYan ChenPublished in: International journal of nanomedicine (2024)
Extracellular vesicles (EVs) are nanoscale lipid bilayer vesicles released during cell activation, cellular damage, or apoptosis. They carry nucleic acids, proteins, and lipids facilitating intercellular communication and activate signaling pathways in target cells. In non-small cell lung cancer (NSCLC), EVs may contribute to tumor growth and metastasis by modulating immune responses, facilitating epithelial-mesenchymal transition, and promoting angiogenesis, while potentially contributing to resistance to chemotherapy drugs. EVs in liquid biopsies serve as non-invasive biomarkers for early cancer detection and diagnosis. Due to their small size, inherent molecular transport properties, and excellent biocompatibility, EVs also act as natural drug delivery vehicles in NSCLC therapy.
Keyphrases
- signaling pathway
- epithelial mesenchymal transition
- cell cycle arrest
- induced apoptosis
- small cell lung cancer
- drug delivery
- pi k akt
- immune response
- oxidative stress
- endoplasmic reticulum stress
- advanced non small cell lung cancer
- cell death
- papillary thyroid
- cell therapy
- transforming growth factor
- single cell
- endothelial cells
- fatty acid
- vascular endothelial growth factor
- stem cells
- cancer therapy
- brain metastases
- loop mediated isothermal amplification
- wound healing
- ultrasound guided
- atomic force microscopy
- drug release
- radiation therapy
- rectal cancer
- chemotherapy induced