Steroid-induced Deficiency of Mucosal-associated Invariant T Cells in the Chronic Obstructive Pulmonary Disease Lung. Implications for Nontypeable Haemophilus influenzae Infection.
Timothy S C HinksJoshua C WallingtonAnthony P WilliamsRatko DjukanovićKarl J StaplesTom M A WilkinsonPublished in: American journal of respiratory and critical care medicine (2017)
MAIT cells are deficient in blood and bronchial tissue in steroid-treated, but not steroid-naive, COPD. NTHi constitutes a target for pulmonary MAIT-cell immune responses, which are significantly impaired by corticosteroids.
Keyphrases
- chronic obstructive pulmonary disease
- immune response
- induced apoptosis
- lung function
- pulmonary hypertension
- single cell
- high glucose
- cell therapy
- diabetic rats
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- drug induced
- signaling pathway
- mesenchymal stem cells
- endothelial cells
- air pollution
- newly diagnosed