Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy.

Mario R FernandezFranz X SchaubChunying YangWeimin LiSeongseok Yun Stephanie K SchaubFrank C DorseyMin LiuMeredith A SteevesAndrea BallabioAlexandar TzankovZhihua ChenJohn M Koomen Anders E Berglund John L Cleveland

Published in: Cancer research (2022)

MYC suppresses TFEB and autophagy and controls amino acid homeostasis by upregulating amino acid transport and the proteasome, and reactivation of TFEB disables the metabolism of MYC-driven tumors.

Keyphrases

amino acid
transcription factor
signaling pathway
cell death
oxidative stress
endoplasmic reticulum stress