Interventional closure vs. medical therapy of patent foramen ovale for secondary prevention of stroke: updated meta-analysis.

Davor VukadinovićStephan H SchirmerAleksandra Nikolovska VukadinovićChristian UkenaBruno SchellerFelix MahfoudMichael Böhm

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2018)

Interventional closure of PFO resulted in significant reduction of stroke and stroke/TIA compared with antiplatelets/anticoagulants with comparable bleeding rates between the groups, whereas AF occurred more frequently in the intervention group. Patients with large shunts had more benefit from interventional closure.

Keyphrases

atrial fibrillation
systematic review
randomized controlled trial
healthcare
stem cells
meta analyses
brain injury
replacement therapy