Characteristics, Antithrombotic Patterns, and Prognostic Outcomes in Claudication and Critical Limb-Threatening Ischemia Undergoing Endovascular Therapy.
Osami KawaradaKan ZenKoji HozawaHideaki ObaraKentaro MatsubaraYoshito YamamotoTatsuki DoijiriNozomu TamaiShigenori ItoAkihiro HigashimoriDaizo KawasakiHideki DoiKensuke MatsushitaKengo TsukaharaKatsuo NodaMasahisa ShimpoYuki TsudaShinjo SonodaTakuya TaniguchiKatsuhisa WasedaMasato MunehisaEiji TaguchiTatsuya KinjoYohei SasakiKenichiro YubaShinichiro YamaguchiTakuo NakagamiShinobu AyabeShingo SakamotoTakeshi YagyuSoshiro OgataKunihiro NishimuraHisashi MotomuraTeruo NoguchiMasaharu IshiharaHisao OgawaSatoshi YasudaPublished in: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists (2022)
The underlying difference between intermittent claudication (IC) and critical limb-threatening ischemia (CLTI) still remains unclear. This prospective multicenter observational study, JPASSION study found that CLTI was characterized not only by more systemic comorbidities and distal disease but also by more inflammatory coagulation disorder compared to IC. Also, CLTI had approximately twice major adverse cardiovascular event (MACE) and reintervention rates than IC. Intriguingly, the underlying inflammatory coagulation disorder per se was independently associated with MACE and reintervention. Further studies to clarify the role of anticoagulation and anti-inflammatory therapies will contribute to the development of post-interventional therapeutics in the context of peripheral artery disease.