Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial.
Miao SunXianghan RuanZhikang ZhouYuting HuoMin LiuSiyuan LiuJiangbei CaoYan-Hong LiuXiaoying ZhangYu-Long MaWei-Dong MiPublished in: Age and ageing (2024)
Intranasal insulin administration is thus suggested as a potential therapy to improve postoperative cognition in older patients undergoing surgery. However, a more standardized multi-centre, large-sample study is needed to further validate these results.
Keyphrases
- patients undergoing
- double blind
- placebo controlled
- clinical trial
- type diabetes
- phase ii
- phase iii
- study protocol
- physical activity
- minimally invasive
- glycemic control
- coronary artery bypass
- randomized controlled trial
- open label
- cardiac surgery
- phase ii study
- mild cognitive impairment
- middle aged
- skeletal muscle
- adipose tissue
- community dwelling
- squamous cell carcinoma
- stem cells
- acute kidney injury
- cell therapy
- bone marrow
- mesenchymal stem cells
- metabolic syndrome