Dynamics of sister chromatids through the cell cycle: Together and apart.

Published in: The Journal of cell biology (2018)

When and how sister chromatid resolution occurs after DNA replication is a fundamental question. Stanyte et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801157) used CRISPR/Cas9 technology to label and track genomic loci in live cells throughout the cell cycle, shedding light on how replication is linked to mitotic sister chromatid organization.

Keyphrases

cell cycle
crispr cas
cell proliferation
induced apoptosis
genome editing
cell cycle arrest
single cell
genome wide
copy number
single molecule
stem cells
genome wide association study
genome wide association