Increased particle size of triacylglycerol-enriched remnant lipoproteins, but not their plasma concentration or lipid content, augments risk prediction of incident type 2 diabetes.
Luiz Sérgio Fernandes de CarvalhoIsabela M BenseñorAna C C NogueiraBruce B DuncanMaria I SchmidtMichael J BlahaPeter P TothSteven R JonesRaul Dias Dos Santos FilhoPaulo A LotufoAndrei C Spositonull nullPublished in: Diabetologia (2020)
TRL particle diameter improves the prediction of diabetes, but only in individuals with HbA1c <39 mmol/mol (5.7%) at baseline. These data support TRL particle diameter as a risk factor that is changed early in the course of the pathophysiological processes that lead to the development of type 2 diabetes, even before glucose abnormalities are established. Graphical abstract.