New drugs against multidrug-resistant Gram-negative bacteria: a systematic review of patents.
María C JiménezLayza KowalskiRicardo B SoutoIzabel Almeida AlvesMax Denisson Maurício VianaDiana Marcela AragónPublished in: Future microbiology (2022)
<b>Background:</b> Antimicrobial resistance has been a threat to human health ever since the accelerated consumption of antibiotics began. <b>Materials & methods:</b> The present systematic review was carried out using a free and specialized online database - Espacenet - and a survey for patents of antimicrobial agents from 2010 to 2021, selecting 33 recent patents that claimed compounds with antimicrobial activity against resistant strains of Gram-negative bacteria. <b>Results:</b> Some different and new approaches to the development of the patented antibacterial agents were identified, such as antimicrobial peptides, nanomaterials and natural extracts. <b>Conclusion:</b> Some alternatives to modern antibiotics with diminished effectiveness due to antimicrobial resistance were spotted. Nevertheless, many challenges remain to establish a robust and sustainable antibacterial R&D pipeline.
Keyphrases
- antimicrobial resistance
- human health
- systematic review
- multidrug resistant
- risk assessment
- protein kinase
- silver nanoparticles
- climate change
- meta analyses
- randomized controlled trial
- escherichia coli
- staphylococcus aureus
- palliative care
- drug resistant
- acinetobacter baumannii
- gram negative
- social media
- anti inflammatory
- emergency department
- essential oil
- wound healing
- healthcare
- pseudomonas aeruginosa