Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway.

Hongyan ZhaoPeng WangXiaohong WangWa DuHui-Hui YangYueying LiuShu-Nan CuiWei HuangTianqing PengJing ChenChen GaoYigang WangSakthivel SadayappanChengen MaYanbo FanChunting WangGuo-Chang Fan

Published in: Cardiovascular research (2023)

This study identifies Lcn10 as a novel regulator of EC function and illustrates a new link in the Lcn10-LRP2-Ssh1 axis to controlling endothelial barrier integrity. Our findings may provide novel strategies for the treatment of inflammation-related diseases.

Keyphrases

signaling pathway
oxidative stress
pi k akt
epithelial mesenchymal transition
endothelial cells
genome wide
induced apoptosis
gene expression
dna methylation
low density lipoprotein
combination therapy
replacement therapy
endoplasmic reticulum stress