Antibiotic De-Escalation Practices in the Intensive Care Unit: A Multicenter Observational Study.
Asad E PatanwalaArwa Abu SardanehJan-Willem C AlffenaarChui Lynn ChooAlexandra L DeyEamon J DuffySarah E GreenThomas E HillsLisa M HowleJessica A JosephMaxkirivan C KhuonCassandra S KoppenFrancis PangJung Yeun ParkMark A ParlickiIsha S ShahKylie TranPriscilla TranMardi A WillsJessica H XuMarian Youssefnull nullPublished in: The Annals of pharmacotherapy (2024)
Timely ADE may not occur in 40% of patients in the ICU and is less likely to occur in patients with negative cultures. Timely ADE can be improved, and patients with negative cultures should be targeted as part of antimicrobial stewardship efforts.