Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation.
Yi-Kuan ChiangYung-Shuan LinChun-Yu ChenJiing-Feng LirngYu-Hsiu YangWei-Ju LeeJong-Ling FuhPublished in: American journal of Alzheimer's disease and other dementias (2024)
Triggering receptor expressed on myeloid cells 2 (TREM2) is upregulated in activated microglia and may be related to cognitive decline in patients with Alzheimer's disease (AD). There is conflicting evidence regarding the association of peripheral TREM2 mRNA expression/soluble TREM2 (the extracellular domain of TREM2) with cognitive function/neuroinflammation in patients with AD. Herein, we studied the TREM2 and TREM2 alt mRNA expression and their association with the cognitive performance in subjects with mild dementia due to AD and healthy controls. In a subgroup of patients with AD, magnetic resonance spectroscopy was used to measure the myo-inositol level in the posterior cingulate cortex, a surrogate marker for neuroinflammation. The results showed that increased TREM2 and TREM2 alt mRNA expression is associated with AD pathogenesis at the mild dementia stage, thereby serving as a potential biomarker for early symptomatic stage of AD. TREM2 may exert protective effects on both cognition and central neuroinflammation.
Keyphrases
- cognitive decline
- mild cognitive impairment
- cognitive impairment
- lipopolysaccharide induced
- induced apoptosis
- traumatic brain injury
- lps induced
- inflammatory response
- cerebral ischemia
- bone marrow
- acute myeloid leukemia
- dendritic cells
- spinal cord injury
- randomized controlled trial
- oxidative stress
- clinical trial
- multiple sclerosis
- cell death
- blood brain barrier
- cell proliferation
- endoplasmic reticulum stress
- signaling pathway