Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response.
Mikhail Y VolkovArieke Suzanna Berendina KampstraKarin A J van SchieAnouk G van MourikJoanneke C KwekkeboomArnoud de RuPeter A van VeelenThomas Wj HuizingaRené E M ToesDiane van der WoudePublished in: RMD open (2024)
Acetylated bacterial proteins are recognisable by hAMPA and are capable of inducing cross-reactive AMPA in mice. These observations provide the first conceptual evidence for a novel mechanism involving the (endogenous) acetylation of the bacterial proteome, allowing a breach of tolerance to modified proteins and the formation of cross-reactive AMPA.