STAT1 epigenetically regulates LCP2 and TNFAIP2 by recruiting EP300 to contribute to the pathogenesis of inflammatory bowel disease.

Ya-Li YuMeng ChenHua ZhuMing-Xing ZhuoPing ChenYu-Juan MaoLian-Yun LiQiu ZhaoMin WuMei Ye

Published in: Clinical epigenetics (2021)

p-STAT1 and EP300 promote TNFAIP2 and LCP2 expression through an increase in H3K27ac enrichment on their enhancers and contribute to the pathogenesis of chronic inflammation.

Keyphrases

cell proliferation
poor prognosis
oxidative stress
long noncoding rna
binding protein
ulcerative colitis