Epigenetic Induction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms and Dissections.

Abhishek Shankar Yanming LiChen ZhangYang Li Kimberly R RebelloShengyu LiSamantha XuHernan G VasquezLin ZhangWei Luo Guangyu Wang Kaifu Chen Joseph Stapleton Coselli Scott A LeMaire Ying H Shen

Published in: Circulation (2023)

Our study reveals the dynamic epigenetic induction of SMC phenotypic alterations in AAD. DNA damage and cytosolic leakage drive SMCs from a contractile phenotype to an inflammatory phenotype.

Keyphrases

smooth muscle
dna damage
dna methylation
oxidative stress
gene expression
aortic valve
cell therapy
skeletal muscle
left ventricular
dna repair
stem cells