Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes.
Fawzy A ElbarbryTamer M IbrahimMohamed A AbdelrahmanClaudiu T SupuranWagdy M EldehnaPublished in: European journal of drug metabolism and pharmacokinetics (2024)
These findings point to the feasibility of utilizing these agents as promising chemopreventive agents (owing to inhibition of CYP2E1), and AW-9A as a smoking cessation aid (owing to inhibition of CYP2A6). Additional in-vivo studies should be conducted to examine the impact of CYP2A6 and CYP2E1 inhibition on drug interactions with probe substrates of these enzymes.