HCC-1 Accelerates Atherosclerosis by Inducing Endothelial Cell and Macrophage Pyroptosis and Serves as an Early Diagnostic Biomarker.
Fan BuJunhui WangJuanjiang ChenQi ZhangXiaomin LinRuyi ZhangHuanlan BaiYuneng HuaHaifang WangMei HuangYiyi HuangYuling LinXiumei HuLei ZhengQian WangPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
HCC-1 expression was increased in patients with atherosclerosis, and HCC-1 overexpression accelerated atherosclerotic burden via an enhancement in monocyte recruitment, M1 polarization, and pyroptosis both in endothelial cells and macrophages. Our findings suggested that HCC-1 may serve as an early biomarker for the diagnosis of atherosclerosis, with the capacity to reflect the degree of stenosis.