Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer.

G-Q ZhangC XiN-T JuC-T ShenZ-L QiuH-J SongQuan-Yong Luo

Published in: Journal of endocrinological investigation (2024)

Thyroid cancer exhibited enhanced glutamine metabolism, as evidenced by the glutamine dependence of thyroid cancer cells and high expression of multiple glutamine metabolism-related genes. Targeting glutamine metabolism with DON prodrug could be a promising therapeutic option for advanced thyroid cancer.

Keyphrases

cancer therapy
poor prognosis
drug delivery