Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis-associated encephalopathy.

Ling LiDu LixiaGuifen GanJin LiLin YangYou WuZongping FangXijing Zhang

Published in: CNS neuroscience & therapeutics (2024)

The accumulation of astrocytic lipid droplets plays a crucial role in the pathological process of SAE. HILPDA is an attractive therapeutic target for lipid metabolism regulation and cognitive improvement in septic patients.

Keyphrases

end stage renal disease
acute kidney injury
fatty acid
chronic kidney disease
newly diagnosed
ejection fraction
peritoneal dialysis
intensive care unit
prognostic factors
type diabetes
metabolic syndrome
adipose tissue
patient reported