Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinoma.
Reham HammadMona A EldosokyAsmaa A ElmadboulyReda Badr AglanSherihan G AbdelHamidSamy ZakyElham AliFatma El-Zahraa Abd El HakamAlshaimaa M MosaadNeamat A AbdelmageedFatma M KotbHend G KotbAhmed A HadyOmaima I Abo-ElkheirSandy KujumdshievUlrich SackClaude LambertNadia M HamdyPublished in: Journal of cancer research and clinical oncology (2023)
Monocyte subsets differentiation in HCC was linked to hsa-miR-21-5p and hsa-miR-155-5p. Combined up-regulation of intermediate monocytes frequency and hsa-miR-21-5p expression could be considered a sensitive indicator of LC progression to HCC. Circulating intermediate monocytes and hsa-miR-21-5p were independent risk factors for HCC evolution, clinically and in silico proved.