Enhancement of Circulating and Intestinal T Regulatory Cells and Their Expression of Helios and Neuropilin-1 in Children with Inflammatory Bowel Disease.

Katarzyna SznurkowskaJustyna LutyEwa BrylJacek M WitkowskiBlanka Hermann-OkoniewskaPiotr LandowskiMarta Kosek Agnieszka Szlagatys Sidorkiewicz

Published in: Journal of inflammation research (2020)

The rates of circulating and intestinal T regulatory cells are increased in naïve pediatric patients with IBD. The rate of Tregs is higher in intestinal mucosa than in peripheral blood in patients with IBD. Flow cytometry is a valuable method assessing the composition of infiltrates in inflamed tissue. Helios and Neuropilin-1 likely cannot serve as markers to differentiate between natural and adaptive Tregs.

Keyphrases

induced apoptosis
flow cytometry
peripheral blood
cell cycle arrest
poor prognosis
ulcerative colitis
cell death
oxidative stress
binding protein