Reirradiation and PD-1 inhibition with nivolumab for the treatment of recurrent diffuse intrinsic pontine glioma: a single-institution experience.

Cassie N KlineS John LiuSai DurisetiAnuradha BanerjeeTheodore NicolaidesShannon RaberNalin GuptaDaphne Haas-KoganSteve BraunsteinSabine Mueller

Published in: Journal of neuro-oncology (2018)

Our experience demonstrates the tolerability of reRT with concurrent PD-1 inhibition for recurrent DIPG and suggests that combination therapy may offer survival benefit. Future prospective studies are needed to confirm the benefits of this combination therapy.

Keyphrases

current status
combination therapy
low grade
locally advanced
randomized controlled trial
squamous cell carcinoma
free survival
high grade
rectal cancer
smoking cessation
replacement therapy