Specific HIF-2α (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP).

Arthur Colson Christophe Louis DepoixIsaline LambertCamille LeducqMarie BedinMichèle De BeukelaerLaurent GattoAxelle LoriotMaureen Peers de NieuwburghKhadija BouhnaPamela BaldinCorinne HubinontPierre SonveauxFrédéric Debiève

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

These results highlight HIF-2α as a new player in our understanding of placental dysfunction and support the use of PT2385 to treat severe preeclampsia in humans.

Keyphrases

early onset
oxidative stress
endothelial cells
pregnancy outcomes
radiation induced