Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene.
Guo-Zhu SunYong-Chang HeXiao Kuang MaShuang-Tao LiDe-Jie ChenMing GaoShen-Feng QiuJun-Xiang YinJiong ShiJie WuPublished in: CNS neuroscience & therapeutics (2017)
Our results suggest significant alterations in hippocampal dendritic structure and synaptic function in Apoe4 mice, even at an early age.