Gold-Catalyzed Cyclization of Ynones Involving cis -Hydrofunctionalizations: Rapid Assembly of C-, O-, or S-Functionalized Pyrroles by a Single Methodology.

A gold-catalyzed cyclization of conjugated ynones with various nucleophiles such as indoles, alcohols, and thiols has been developed. The reaction provides a new and efficient protocol for the synthesis of functionalized pyrroles with wide versatility and functional group compatibility. Remarkably, for indolyl, alkoxy, or sulfenyl pyrroles, all could be constructed efficiently by this single methodology. In addition, cis -hydrofunctionalizations of ynones are involved in these reactions.