WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer.
Kerstin MenckSaskia HeinrichsDarius WlochowitzMaren SitteHelen NoedingAndreas JanshoffHannes TreiberTorben RuhwedelBawarjan SchatloChristian von der BrelieStefan WiemannTobias PukropTim BeißbarthClaudia BinderAnnalen BleckmannPublished in: Journal of experimental & clinical cancer research : CR (2021)
Taken together, our study revealed a novel auto-stimulatory loop in which ROR2 triggers the expression of its own ligand, WNT11, resulting in enhanced tumor invasion associated with breast cancer metastasis.