The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia.
Natanja OosteromM FioccoR Q H KloosI M van der SluisR PietersB D van ZelstD E C SmithM M van den Heuvel-EibrinkR de JongeS G HeilPublished in: BMC cancer (2020)
These results suggest that the increase in RBC folate levels does not seem to have a large effect on RBC MTX levels. Future studies, assessing competition of Leucovorin and MTX on other cellular mechanisms which might negatively affect treatment efficacy, are necessary.